Pirenzepine Hydrochloride: Subtype-Selective Pharmacology as a Blueprint for Repurposing
Pirenzepine hydrochloride stands out in the pharmacology landscape as a muscarinic M1-selective antagonist with a track record in reducing gastric acid secretion. Historically prescribed for peptic ulcers, its subtype selectivity offered a cleaner anticholinergic profile than nonselective agents-an attribute that today matters as the industry grapples with on-target efficacy and off-target cognitive risk. In an …
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